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KMID : 0043320080310091160
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Archives of Pharmacal Research
2008 Volume.31 No. 9 p.1160 ~ p.1165
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Morin Protects Acute Liver Damage by Carbon Tetrachloride (CCl4) in Rat
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Lee Hee-Seung
Hong Soon-Sun
Lee Don-Haeng
Han Hyo-Kyung
Jung Kyung-Hee
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Abstract
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The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.
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KEYWORD
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Morin, Antioxidant, Carbon tetrachloride (CCl4), Hepatic toxicity
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